Physicians often encounter challenges in diagnosing non-optic intraparenchymal lesions on MRI brain scans of patients with neurofibromatosis type 1. Due to unclear incidence and evolution of these lesions into adulthood, we conducted a retrospective study on the subject. Our findings indicated that asymptomatic glioma-like lesions on MRI brain scans of neurofibromatosis type 1 patients, whether they show contrast enhancement or mass effect, tend to be indolent. This suggests that mildly symptomatic or asymptomatic patients can be monitored without the need for invasive diagnostic and therapeutic procedures.
Our findings support the recommendations of the ERN GENTURIS tumour surveillance guidelines.
